Protective Effect of Lycopene against Genotoxicity of Nickel Sulfate in Rats

Aim: Nickel, which has a wide usage area in industries, teratogenic, carcinogenic, immunotoxic, and genotoxic effects. In this study, the protective effects of lycopene, antioxidant properties, were investigated against genotoxicity caused by nickel sulfate. Materials Methods: total 24 rats (Wistar albino) divided into four groups: Group I (control) daily saline intraperitoneal (i.p.) corn oil oral gavage (0.5 ml); II sulfate (20 mg/kg, i.p.) was dissolved physiological saline; III lycopene ml) suspended at 20 mg/kg doses; IV given doses, 2 hours later, administered for 21 days. Micronucleated polychromatic erythrocytes (MNPCE) (PCE) examined bone marrow micronucleus test, is one tests. Results: It determined that administration preventive purposes decreased MNPCE levels significantly (p